Duo consolidates Analogue's FPGA approach across NEC's entire home console lineup — TurboGrafx-16, PC Engine, SuperGrafx, and their CD-ROM variants — into one all-in-one system with an original-style cartridge slot, controller port, and built-in CD-ROM drive. It's the first Analogue console to include a disc drive, covering HuCards, TurboChips, and CD-ROM games from a single unit.

Bluetooth and 2.4G wireless connectivity join wired USB support, running on Analogue's own DuoOS interface first introduced with the Pocket. HDMI output covers up to 1080p, and the Altera Cyclone V FPGA recreates each system's core functionality at the circuit level rather than through emulation.